Diphenhydramine Dosing Chart

Diphenhydramine (Benadryl®)

Dosing Guidelines for Benadryl® (diphenhydramine)

1 teaspoonful (5 mL) = 12.5 mg of diphenhydramine



Age (in years) Dose
Under 6 years Ask a doctor
6 years to 12 years 1 – 2 teaspoonfuls (12.5 mg to 25 mg)
12 years old or older 2-4 teaspoonfuls (25 mg to 50 mg)

May repeat every 4 to 6 hours, not to exceed 6 doses in 24 hours.

**Always use a dropper, oral syringe, or cup with clear markings.  Do not use household utensils to measure a dose because they can vary.

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